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Biography

Gabriela Hr?kova graduated from the University of P. J. Šafárik, Faculty of Sciences in Košice, (Slovakia), where she completed Master’s degree in biology. She achieved PhD degree in 1993 at the Institute of Parasitology, Slovak Academy of Sciences and became a staff member. Her present position is principal investigator and Head of laboratory of Experimental Pharmacology at this Institute. Since 1997 she participates in pre-graduate and post graduate education both as supervisor and lecturer at Faculty of Sciences, Šafárik University. Since 2009 she also works for private Pharmaceutical Company (ImmunaPharm) in Slovakia as consultant for molecular and cell biology. Her research has been awarded by grants from the Royal Society of UK, Wellcome Trust London, ÖAD Austria, EU “Synthesis” and by several fellowships. She is author or co-author of over 60 scientific papers, 3 book chapters and one book published in series SpringerBrief, which are indexed in WOS/Scopus. Her background in pharmacology of infectious diseases extends over more than 25 years of research. Main research interests cover the effects of anthelmintic drugs and natural compounds, drug carriers and immunomodulators using in vitro and in vivo experimental settings, as well as interests in mechanisms of host-parasites interactions.

Abstract

Larval stage of flatworm, tetrathyridium, has ability of survival and asexual multiplication in a wide range of vertebrate hosts what indicates a high biochemical and physiological potential for adaptation. We recently developed axenic long-term in vitro cultivation systems of larvae under both hypoxic and aerobic conditions, representing the unique eukaryotic model for pharmacological and molecular studies. This in vitro system allowed us to study the dose- and time-dependent effects of various natural compounds on multiple biochemical and molecular pathways in larvae. We have focussed on flavonolignans (silybin, dehydrosilybin and silychristin) prepared from silymarin, the main component of herb Silybum marrianum and two other flavonoids: bergenin and arbutin. Activity of individual compounds on metabolic activity of larvae, which reflects activity of enzymes of complex I and II in mitochondria, was dependent on oxygen tension in culture. Flavonolignans also modulated activity of other enzymes like GST, SOD, enzymes involved in glucose transport, in lipogenesis, cell death and motility, indicating their complex activity on multiple targets in larvae.

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Regarding refunds, all bank charges will be for the registrants account.

This cancellation policy was last updated on March 20, 2017.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to 
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Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to ethnopharmacology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

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Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
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