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Rusli Ismail completed PharmD at the University of Minnesota in 1983 and joined Universiti Sains Malaysia as a lecturer where he developed TDM and clinical pharmacy. He left USM as Professor and Director at its Institute for Research in Molecular Medicine in 2012 to head the Centre of Excellence in Research in HIV/AIDS at Universiti Malaya. In 2017, Rusli joined UnisZA at its new Faculty of Medicine where he also currently chairs its Human Ethics Committee. He has supervised more than 30 graduate students and published extensively in reputed journals. He helped pioneered the introduction of harm reduction in Malaysia to fight HIV/AIDS.